A Dangerous Vitious Circle of the Neonatal Brain in Bilirubin- Induced Neurologic Dysfunction (BIND)
نویسندگان
چکیده
منابع مشابه
A Dangerous Vitious Circle of the Neonatal Brain in Bilirubin- Induced Neurologic Dysfunction (BIND)
On the basis of abundant research data and hypotheses the BIND is a neurodegenerative disease (ND) of immature brain caused by accumulation of free copper ions, unconjugated bilirubin (UCB), and UCB-Cu complex (as prooxidant), respectively, in the basal ganglia (BG) and other parts of the central nervous system (CNS) relevant to BIND. The main comorbidity is the hemolysis of neonatal red blood ...
متن کاملNew Concept of Bilirubin-Induced Neurologic Dysfunction: Neonatal Brain Insults of Metal (Copper) Dyshomeostasis
Excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal excess may result in permanent injuries, including severe neurological disorders. The immature and strikingly vulnerable neurons play an important role in the pathogenesis of bilirubin-induced neurol...
متن کاملBilirubin/Albumin Ratio for Predicting Acute Bilirubin-induced Neurologic Dysfunction
OBJECTIVE The aim of this study was to evaluate the bilirubin albumin (B/A) ratio in comparison with total serum bilirubin (TSB) for predicting acute bilirubin-induced neurologic dysfunction (BIND). METHODS Fifty two term and near term neonates requiring phototherapy and exchange transfusion for severe hyperbilirubinemia in Children's Medical Center, Tehran, Iran, during September 2007 to Sep...
متن کاملImpact of bilirubin-induced neurologic dysfunction on neurodevelopmental outcomes.
Bilirubin-induced neurologic dysfunction (BIND) is the constellation of neurologic sequelae following milder degrees of neonatal hyperbilirubinemia than are associated with kernicterus. Clinically, BIND may manifest after the neonatal period as developmental delay, cognitive impairment, disordered executive function, and behavioral and psychiatric disorders. However, there is controversy regard...
متن کاملA modified Bilirubin-induced neurologic dysfunction (BIND-M) algorithm is useful in evaluating severity of jaundice in a resource-limited setting
BACKGROUND Severe neonatal jaundice with associated acute bilirubin encephalopathy occurs frequently in low- and middle-income countries, where advanced diagnostic technology is in short supply. In an effort to facilitate the physical diagnosis of acute bilirubin encephalopathy, we pilot-tested a modified bilirubin induced neurologic dysfunction scoring algorithm in a group of pediatric trainee...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: MOJ Bioequivalence & Bioavailability
سال: 2017
ISSN: 2573-2951
DOI: 10.15406/mojbb.2017.03.00038